Genomic Copy Number Alterations in Renal Cell Carcinoma with Sarcomatoid Features

Sarcomatoid Chromophobe Renal Cell Carcinoma with Heterologous Component

Clear cellrenal cell carcinoma (RCC) is the most common malignant renal tumor in adults, while chromophobe RCC (CRCC) is the third most common. Any subtypes of RCC can undergo sarcomatoid differentiation, but heterologous differentiation in sarcomatoid area is very rare in RCC. Here a61-year male is presented with hematuria and palpable mass. Clinicoradiologically, RCC was considered and left r...

Sarcomatoid Transrormation of Chromophobe Renal Cell Carcinoma

Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation

We report chromophobe renal cell carcinoma (CRCC) with sarcomatoid dedifferentiation in a sixty-five year old male. CRCC is a prognostically better, distinctive subtype of renal cell carcinoma (RCC), histologically characterized by cells containing translucent and reticulated cytoplasm with distinct cell borders. Sarcomatoid component accompanies 9% of CRCC which alters its prognostic implicati...

sarcomatoid transrormation of chromophobe renal cell carcinoma

BIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer

Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...